Vertebrate and insect haemoglobins
نویسندگان
چکیده
منابع مشابه
Evolution of vertebrate haemoglobins: Histidine side chains, specific buffer value and Bohr effect.
This review highlights the use of analytical tools, recently developed in the comparative method of evolutionary biology, for the study of haemoglobin (Hb) adaptation. It focuses on the functional consequences of a previously largely ignored structural feature of Hb, namely the degree and positional specificity of histidine (His) substitution in Hb chains. The importance of His side chains for ...
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Haemoglobin has been the subject of intensive research for many years and is one of the most thoroughly understood of all protein molecules. The amino-acid sequences of haemoglobins from many species of animals have been determined (tabulated by Dayhoff, 1969) and the molecular structures of horse and human haemoglobins have been determined in great detail by x-ray crystallography (Perutz et al...
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We have conducted a comprehensive search for conserved elements in vertebrate genomes, using genome-wide multiple alignments of five vertebrate species (human, mouse, rat, chicken, and Fugu rubripes). Parallel searches have been performed with multiple alignments of four insect species (three species of Drosophila and Anopheles gambiae), two species of Caenorhabditis, and seven species of Sacch...
متن کاملDesign Principles of Insect and Vertebrate Visual Systems
A century ago, Cajal noted striking similarities between the neural circuits that underlie vision in vertebrates and flies. Over the past few decades, structural and functional studies have provided strong support for Cajal's view. In parallel, genetic studies have revealed some common molecular mechanisms controlling development of vertebrate and fly visual systems and suggested that they shar...
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Haemoglobin (Hb) abnormalities though quite frequent, are generally detected in populations during surveys and programmes run for prevention of Hb disorders. Several methods are now available for detection of Hb abnormalities. In this review, the following are discussed: (i) the methods used for characterization of haemoglobin disorders; (ii) the problems linked to diagnosis of thalassaemic tra...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1970
ISSN: 0306-3283
DOI: 10.1042/bj1190031pb